endTB-Q clinical trial results slides from the Union World Conference 2024
Topics
- endTB-Q Clinical Trial
The slides from the presentation on the endTB-Q clinical trial results at the 2024 Union Conference in Bali are accessible here.
Comparative effectiveness of adding delamanid to a multidrug-resistant tuberculosis regimen comprised of three drugs likely to be effective
Topics
- endTB Observational Study
ABSTRACT
Estimating post-treatment recurrence after multidrug-resistant tuberculosis treatment among patients with and without HIV: the impact of assumptions about death and missing follow-up
Topics
- endTB Observational Study
Abstract
Background
Quantification of recurrence risk following successful treatment is crucial to evaluating regimens for multidrug- or rifampicin-resistant (MDR/RR) tuberculosis (TB). However, such analyses are complicated when some patients die or become lost during post-treatment follow-up.
Cardiac safety of multidrug-resistant tuberculosis treatment: moving towards individualized monitoring
Topics
- endTB Observational Study
ABSTRACT
Effectiveness of a bedaquiline, linezolid, clofazimine "core" for multidrug-resistant tuberculosis
ABSTRACT
RATIONALE: Treatment outcomes may be compromised among patients with multidrug- or rifampicin-resistant tuberculosis with additional fluoroquinolone resistance. Evidence is needed to inform optimal treatment for these patients.
OBJECTIVES: We compared the effectiveness of longer individualized regimens comprised of bedaquiline for 5 to 8 months, linezolid, and clofazimine to those reinforced with at least 1 third-tier drug and/or longer duration of bedaquiline.
Pregnancy and Birth Outcomes in Patients With Multidrug-Resistant Tuberculosis Treated With Regimens That Include New and Repurposed Drugs
Topics
- endTB Observational Study
ABSTRACT
Among 43 pregnant women receiving multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment with bedaquiline and/or delamanid, 98% had favorable treatment outcomes. Of 31 continued pregnancies, 81% had live births with no reported malformations, and 68% of neonates had normal birth weights. Effective MDR/RR-TB treatment during pregnancy can improve maternal outcomes without harming neonates.
Outcomes of WHO-conforming, longer, all-oral multidrug-resistant TB regimens and analysis implications
Topics
- endTB Observational Study
ABSTRACT
Effectiveness of Bedaquiline Use beyond Six Months in Patients with Multidrug-Resistant Tuberculosis
Topics
- endTB Observational Study
ABSTRACT
RATIONALE: Current recommendations for the treatment of rifampin- and multidrug-resistant tuberculosis include bedaquiline used for six months or longer. Evidence is needed to inform the optimal duration of bedaquiline.
OBJECTIVES: We emulated a target trial to estimate the effect of three bedaquiline duration treatment strategies (6 months, 7-11 months, ≥ 12 months) on the probability of successful treatment among patients receiving a longer individualized regimen for multidrug-resistant tuberculosis.
Selection bias in multidrug-resistant tuberculosis cohort studies assessing sputum culture conversion
Concordance of three approaches for operationalizing outcome definitions for multidrug-resistant TB
Topics
- endTB Observational Study
ABSTRACT
