Standards for clinical trials for treating TB
ABSTRACT
Novel FujiLAM assay to detect tuberculosis in HIV-positive ambulatory patients in four African countries: a diagnostic accuracy study
SUMMARY
Background
Development of rapid biomarker-based tests that can diagnose tuberculosis using non-sputum samples is a priority for tuberculosis control. We aimed to compare the diagnostic accuracy of the novel Fujifilm SILVAMP TB LAM (FujiLAM) assay with the WHO-recommended Alere Determine TB-LAM Ag test (AlereLAM) using urine samples from HIV-positive patients.
Methods
Diagnostic yield of urine lipoarabinomannan and sputum tuberculosis tests in people living with HIV: a systematic review and meta-analysis of individual participant data
SUMMARY
Background
Sputum is the most widely used sample to diagnose active tuberculosis, but many people living with HIV are unable to produce sputum. Urine, in contrast, is readily available. We hypothesised that sample availability influences the diagnostic yield of various tuberculosis tests.
Methods
Reversing the neglect of children and adolescents affected by tuberculosis
Although tuberculosis is preventable and curable, it remains among the top ten causes of death in children younger than 5 years globally. More than 80% of children who die from tuberculosis are younger than 5 years, and 96% die without ever receiving appropriate care. Estimates from WHO indicate that in 2021, 1·2 million children (aged <10 years) and young adolescents (aged 10–14 years) developed tuberculosis, and 209 000 died from the disease.
Target product profiles: tests for tuberculosis treatment monitoring and optimization
ABSTRACT
Comparative effectiveness of adding delamanid to a multidrug-resistant tuberculosis regimen comprised of three drugs likely to be effective
ABSTRACT
TB treatment using family members, treatment supporters and self-administered therapies in rural Papua New Guinea
ABSTRACT
Estimating post-treatment recurrence after multidrug-resistant tuberculosis treatment among patients with and without HIV: the impact of assumptions about death and missing follow-up
Abstract
Background
Quantification of recurrence risk following successful treatment is crucial to evaluating regimens for multidrug- or rifampicin-resistant (MDR/RR) tuberculosis (TB). However, such analyses are complicated when some patients die or become lost during post-treatment follow-up.
Experiences and perceptions of urine sampling for tuberculosis testing among HIV patients: a multisite qualitative descriptive study
Abstract
Objectives Evidence on the acceptability of urine-based assays for tuberculosis (TB) diagnosis among patients remains limited. We sought to describe patients’ experiences and perceptions of urine sampling for TB testing at point of care.
Setting Study sites in Kenya, Uganda, Mozambique and South Africa.
Participants Adult ambulatory HIV patients enrolled in a TB diagnostic study were selected purposively.
