endTB in South Africa

Implementer: Médecins Sans Frontières (Khayelitsha), Interactive Research and Development (Durban)

Site: Khayelitsha (township on the outskirts of Cape Town) and Durban

South Africa has one of the highest TB incidence rates in the world (834 per 100,000 population). The country accounts for about 15% of the global burden of reported MDR-TB and about 73% of the burden in Africa. The diagnosis and management of drug resistant cases is also very costly for the government: they represent nearly half of the TB budget, with a treatment success rate of only 49% for MDR-TB.

South Africa also suffers from very high HIV-TB co-infection rates: two in three TB patients also have HIV. The estimated national HIV prevalence among the general population aged 15-49 years has remained at 17.3% since 2005.

In 2015, for the first time in South Africa, a patient with extensively drug-resistant TB (XDR-TB) was started on a combination of drugs including delamanid and bedaquiline.